Thyroid nodules (TNs) are frequently encountered in clinical practice; they are usually asymptomatic and, in recent years, appear to have increased in incidence as a result of the widely use of ultrasound (US). Most TNs are benign; therefore, they are usually monitored clinically until they start to cause compressive symptoms, become cosmetically problematic, develop autonomous functions, or prove to be cytological malignancies. Historically, surgery has been considered as the only therapeutic option for TNs. However, being an invasive procedure, surgery - even partial thyroidectomy - for such nodules is associated with minor risks of several complications, including iatrogenic hypothyroidism, scarring, hematoma, dysphonia, and injury to other structures. Thus, minimally invasive US-guided techniques, such as radiofrequency ablation (RFA), have recently been introduced to manage TNs, and shown promising results for volume reduction of TNs and the elimination of hyperthyroidism due to toxic nodules. In addition, RFA has a safety profile comparable in contrast with that of surgery. In summary, given its relatively low complication rate, minimally invasive nature, and thyroid function preservation—as well as the wide availability of radiofrequency generators—RFA is increasingly being applied for the management of thyroid diseases, particularly benign TNs. I present a review of the current literature regarding the feasibility, efficacy, and safety of RFA for the treatment of TNs.