目錄/各期文章

內科學誌 -第32卷第5期

病例 
Discordance of Rifampin Resistance Result by GeneXpert MTB/RIF, Phenotypic and Molecular Methods in A TB Patient  全文閱讀
356~362 
英文 
Mycobacterium tuberculosis、GeneXpert MTB/RIF、Silent mutation P520P 
吳哲慰1 、余秀珊2 、白雅文3 、莊寒玉1 、陳志豪4  
台東馬偕紀念醫院胸腔醫學科1 、衛生福利部台東醫院醫事檢驗科2 、台灣抗結核協會3 、衛生福利部台東醫院內科4  
GeneXpert MTB/RIF can quickly detect Mycobacterium tuberculosis and whether it is a drug-resistant strain to provide doctors with accurate medication treatment and prevention. This case presented to the doctor due to urogenital discomfort. The chest radiography(CXR) during hospitalization revealed an abnormality. The sputum acid fast staining in the laboratory was positive, and the sputum and urine samples were sent for GeneXpert MTB/RIF. It is positive for MTB and resistant to Rifampin (RIF). But it is found that Rifampin (RIF) is sensitive through gold standard LJ proportion drug susceptibility (LJ-DST). After further genetic analysis, it was found that the gene rpoB had silent mutation P520P (silent mutation P520P), so the susceptibility of rifampin was judged to be sensitive. This similar genomic mutation cases are really rare and there were only 8 cases reported in Taiwan.