Inhalants for recreational use in the United States rise in the 1950s and is widespread among adolescents now. The main use of inhalants is for entertainment. After inhalation, nitrous oxide can be rapidly absorbed into the blood through the alveolar capillaries and act neurologic effect. Nitrous oxide related neurologic dysfunction was related to serum vitamin B12 levels decline. Acute and chronic nitrous oxide intoxication will lead to central nervous system(CNS), pulmonary and cardiovascular damages including confusion, pneumonitis, dyspnea and arrhythmia. The treatment of nitrous-oxide induced neuropathy can be alleviated by ceasing nitrous oxide use, vitamin B12 supplements.