Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is the most common form of acute antibodymediated encephalitis, and is known to be associated with ovarian teratomas, especially in young women. However, there is often no clear provoked factor, particularly in children and young men. In recent studies, herpes-simplex virus encephalitis or other virus induced encephalitis have been considered as potential immunological triggers for acute anti-NMDA and other types of autoantibody-mediated encephalitis. The current study demonstrated a young man suffering from anti-NMDA receptor encephalitis soon after left cerebritis and increased intracranial pressure were well treated.